Oddělení toxikogenomiky

2023

Heczko L, Hlaváč V, Holý P, Dvořák P, Liška V, Vyčítal O, Fiala O, Souček P. Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases. Cancer Cell Int 2023; 23:295. doi: 10.1186/s12935-023-03135-x. IF₂₀₂₂ = 5.8

Hlaváč V, Červenková L, Šůsová S, Holý P, Liška V, Vyčítal O, Šorejs O, Fiala O, Daum O, Souček P. Exome Sequencing of Paired Colorectal Carcinomas and Synchronous Liver Metastases for Prognosis and Therapy Prediction. JCO Precision Oncol 2023; 7:e2200557. doi: 10.1200/PO.22.00557. IF₂₀₂₂ = 4.6

Alexander JL, Posma JM, Scott A, Poynter L, Mason SE, Doria ML, Herendi L, Roberts L, McDonald JAK, Cameron S, Hughes DJ, Liska V, Susova S, Soucek P, Horneffer-van der Sluis V, Gomez-Romero M, Lewis MR, Hoyles L, Woolston A, Cunningham D, Darzi A, Gerlinger M, Goldin R, Takats Z, Marchesi JR, Teare J, Kinross J. Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer. Microbiome 2023;11(1):100. doi: 10.1186/s40168-023-01518-w. IF₂₀₂₂ = 15.5

Campa D, Gentiluomo M, Stein A, Aoki MN, Oliverius M, Vodičková L, Jamroziak K, Theodoropoulos G, Pasquali C, Greenhalf W, Arcidiacono PG, Uzunoglu F, Pezzilli R, Luchini C, Puzzono M, Loos M, Giaccherini M, Katzke V, Mambrini A, Kiudeliene E, Federico KE, Johansen J, Hussein T, Mohelnikova-Duchonova B, van Eijck CHJ, Brenner H, Farinella R, Pérez JS, Lovecek M, Büchler MW, Hlavac V, Izbicki JR, Hackert T, Chammas R, Zerbi A, Lawlor R, Felici A, Götz M, Capurso G, Ginocchi L, Gazouli M, Kupcinskas J, Cavestro GM, Vodicka P, Moz S, Neoptolemos JP, Kunovsky L, Bojesen SE, Carrara S, Gioffreda D, Morkunas E, Abian O, Bunduc S, Basso D, Boggi U, Wlodarczyk B, Szentesi A, Vanella G, Chen I, Bijlsma MF, Kiudelis V, Landi S, Schöttker B, Corradi C, Giese N, Kaaks R, Peduzzi G, Hegyi P, Morelli L, Furbetta N, Soucek P, Latiano A, Talar-Wojnarowska R, Lindgaard SC, Dijk F, Milanetto AC, Tavano F, Cervena K, Erőss B, Testoni SG, Verhagen-Oldenampsen JHE, Małecka-Wojciesko E, Costello E, Salvia R, Maiello E, Ermini S, Sperti C, Holleczek B, Perri F, Skieceviciene J, Archibugi L, Lucchesi M, Rizzato C, Canzian F. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years‘ experience of association studies to understand the genetic architecture of pancreatic cancer. Crit Rev Oncol Hematol. 2023;186:104020. doi: 10.1016/j.critrevonc.2023.104020. IF₂₀₂₂ = 6.2

Flasarova D, Urban K, Strouhal O, Klos D, Lemstrova R, Dvorak P, Soucek P, Mohelnikova-Duchonova B. DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC. Int J Mol Sci. 2023;24:8868. doi: 10.3390/ijms24108868. IF₂₀₂₂ = 5.6

Corradi C, Lencioni G, Gentiluomo M, Felici A, Latiano A, Kiudelis G, van Eijck CHJ, Marta K, Lawlor RT, Tavano F, Boggi U, Dijk F, Cavestro GM, Vermeulen RCH, Hackert T, Petrone MC, Uzunoğlu FG, Archibugi L, Izbicki JR, Morelli L, Zerbi A, Landi S, Stocker H, Talar-Wojnarowska R, Di Franco G, Hegyi P, Sperti C, Carrara S, Capurso G, Gazouli M, Brenner H, Bunduc S, Busch O, Perri F, Oliverius M, Hegyi PJ, Goetz M, Scognamiglio P, Mambrini A, Arcidiacono PG, Kreivenaite E, Kupcinskas J, Hussein T, Ermini S, Milanetto AC, Vodicka P, Kiudelis V, Hlaváč V, Soucek P, Theodoropoulos GE, Basso D, Neoptolemos JP, Nóbrega Aoki M, Pezzilli R, Pasquali C, Chammas R, Testoni SGG, Mohelnikova-Duchonova B, Lucchesi M, Rizzato C, Canzian F, Campa D. Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma. J Med Genet. 2023; 60(10):980-986. doi: 10.1136/jmg-2022-108910. IF₂₀₂₂ = 4.0

Spalenkova A, Ehrlichova M, Wei S, Guengerich FP, Soucek P. Effects of 7-ketocholesterol on tamoxifen efficacy in breast carcinoma cell line models in vitro. J Steroid Biochem Mol Biol. 2023;232:106354. doi: 10.1016/j.jsbmb.2023.106354. IF₂₀₂₂ = 4.1

Piccardi M, Gentiluomo M, Bertoncini S, Pezzilli R, Erőss B, Bunduc S, Uzunoglu FG, Talar-Wojnarowska R, Vanagas T, Sperti C, Oliverius M, Aoki MN, Ermini S, Hussein T, Boggi U, Jamroziak K, Maiello E, Morelli L, Vodickova L, Di Franco G, Landi S, Szentesi A, Lovecek M, Puzzono M, Tavano F, van Laarhoven HWM, Zerbi A, Mohelnikova-Duchonova B, Stocker H, Costello E, Capurso G, Ginocchi L, Lawlor RT, Vanella G, Bazzocchi F, Izbicki JR, Latiano A, Bueno-de-Mesquita B, Ponz de Leon Pisani R, Schöttker B, Soucek P, Hegyi P, Gazouli M, Hackert T, Kupcinskas J, Poskiene L, Tacelli M, Roth S, Carrara S, Perri F, Hlavac V, Theodoropoulos GE, Busch OR, Mambrini A, van Eijck CHJ, Arcidiacono P, Scarpa A, Pasquali C, Basso D, Lucchesi M, Milanetto AC, Neoptolemos JP, Cavestro GM, Janciauskas D, Chen X, Chammas R, Goetz M, Brenner H, Archibugi L, Dannemann M, Canzian F, Tofanelli S, Campa D. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians. Biol Res. 2023;56(1):46. doi: 10.1186/s40659-023-00457-y. IF₂₀₂₂ = 6.7

Holý P, Brynychová V, Šeborová K, Haničinec V, Koževnikovová R, Trnková M, Vrána D, Gatěk J, Kopečková K, Mrhalová M, Souček P. Integrative analysis of mRNA-miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer. Mol Oncol. 2023; 17(10):2074-2089. doi: 10.1002/1878-0261.13495. IF₂₀₂₂ = 6.6

Tesarova T, Koucka K, Vaclavikova R, Seborova K, Hora M, Hes O, Pivovarcikova K, Soucek P, Fiala O. Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma. Oncol Lett. 2023;26(3):365. doi: 10.3892/ol.2023.13951. IF₂₀₂₂ = 2.9

Hlaváč V, Holý P, Souček P. The potential of exome sequencing of paired colorectal tumors and synchronous liver metastases to improve treatment. Pharmacogenomics. 2023; 24(13):697-699. doi: 10.2217/pgs-2023-0158. IF₂₀₂₂ = 2.1

Červenková L, Palek R, Moulisova V, Liška V, Daum O, Mohelnikova-Duchonova B, Souček P. Protein expression and localization of ABC transporters in pancreatic adenocarcinoma: prognostic role of ABCC8. Pancreatology 2023; 23(8): 978-987. doi: 10.1016/j.pan.2023. IF₂₀₂₂ = 3.6

Galati L, Gupta P, Tufaro A, Marinaro M, Saponaro C, Escobar Marcillo DI, Loisi D, Sen R, Robitaille A, Brancaccio RN, Cuenin C, McKay-Chopin S, Paradiso AV, Liška V, Souček P, Zito FA, Hughes DJ, Tommasino M, Gheit T. Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples. Infect Agent Cancer. 2023;18(1):71. doi: 10.1186/s13027-023-00552-5. IF₂₀₂₂ = 3.7

Giaccherini M, Gori L, Gentiluomo M, Farinella R, Cervena K, Skieceviciene J, Dijk F, Capurso G, Vezakis A, Archibugi L, Chammas R, Hussein T, Tavano F, Hegyi P, Lovecek M, Izbicki J, Brenner H, Mohelnikova-Duchonova B, Dell’Anna G, Kupcinskas J, Ermini S, Aoki MN, Neoptolemos JP, Gazouli M, Pasquali C, Pezzilli R, Talar-Wojnarowska R, Oliverius M, Al-Saeedi M, Lucchesi M, Furbetta N, Carrara S, van Eijck CHJ, Maleckas A, Milanetto AC, Lawlor RT, Schöttker B, Boggi U, Morelli L, Ginocchi L, Ponz de Leon R, Sperti C, Zerbi A, Arcidiacono PG, Uzunoglu FG, Bunduc S, Holleczek B, Gioffreda D, Małecka-Wojciesko E, Kiudelis M, Szentesi A, van Laarhoven HWM, Soucek P, Götz M, Erőss B, Cavestro GM, Basso D, Perri F, Landi S, Canzian F, Campa D. A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma. Carcinogenesis. 2023; 44(8-9):642-649. doi: 10.1093/carcin/bgad056. IF₂₀₂₂ = 4.7

Daniel P, Balušíková K, Václavíková R, Šeborová K, Ransdorfová Š, Valeriánová M, Wei L, Jelínek M, Tlapáková T, Fleischer T, Kristensen VN, Souček P, Ojima I, Kovář J. ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines. Genes (Basel). 2023;14(2):296. doi: 10.3390/genes14020296. IF₂₀₂₂ = 3.5

Nodari Y, Gentiluomo M, Mohelnikova-Duchonova B, Kreivenaite E, Milanetto AC, Skieceviciene J, Landi S, Lawlor RT, Petrone MC, Arcidiacono PG, Lovecek M, Gazouli M, Bijlsma MF, Morelli L, Kiudelis V, Tacelli M, Zanette DL, Soucek P, Uzunoglu F, Kaaks R, Izbicki J, Boggi U, Pezzilli R, Mambrini A, Pasquali C, van Laarhoven HW, Katzke V, Cavestro GM, Sperti C, Loos M, Latiano A, Erőss B, Oliverius M, Johnson T, Basso D, Neoptolemos JP, Aoki MN, Greenhalf W, Vodicka P, Archibugi L, Vanella G, Lucchesi M, Talar-Wojnarowska R, Jamroziak K, Saeedi MA, van Eijck CHJ, Kupcinskas J, Hussein T, Puzzono M, Bunduc S, Götz M, Carrara S, Szentesi A, Tavano F, Moz S, Hegyi P, Luchini C, Capurso G, Perri F, Ermini S, Theodoropoulos G, Capretti G, Palmieri O, Ginocchi L, Furbetta N, Canzian F, Campa D. Genetic and non-genetic risk factors for early-onset pancreatic cancer. Dig Liver Dis. 2023; S1590-8658(23):00514-5. doi: 10.1016/j.dld.2023.02.023. IF₂₀₂₂ = 4.5

Giaccherini M, Farinella R, Gentiluomo M, Mohelnikova-Duchonova B, Kauffmann EF, Palmeri M, Uzunoglu F, Soucek P, Petrauskas D, Cavestro GM, Zykus R, Carrara S, Pezzilli R, Puzzono M, Szentesi A, Neoptolemos J, Archibugi L, Palmieri O, Milanetto AC, Capurso G, van Eijck CHJ, Stocker H, Lawlor RT, Vodicka P, Lovecek M, Izbicki JR, Perri F, Kupcinskaite-Noreikiene R, Götz M, Kupcinskas J, Hussein T, Hegyi P, Busch OR, Hackert T, Mambrini A, Brenner H, Lucchesi M, Basso D, Tavano F, Schöttker B, Vanella G, Bunduc S, Petrányi Á, Landi S, Morelli L, Canzian F, Campa D. Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk. Int J Cancer. 2023; 153(2):373-379. doi: 10.1002/ijc.34383. IF₂₀₂₂ = 6.4

Dvorak P, Hanicinec V, Soucek P. The longest intron rule. Front Genetics 2023;13:1085139, doi: 10.3389/fgene.2022.1085139. IF₂₀₂₂ = 3.7

2022

Hlaváč V, Holý P, Václavíková R, Rob L, Hruda M, Mrhalová M, Černaj P, Bouda J, Souček P. Whole Exome Sequencing of Epithelial Ovarian Carcinomas Differing in Resistance to Platinum Therapy. Life Sci Alliance 2022;5(12):e202201551. doi: 10.26508/lsa.202201551. IF₂₀₂₁ = 5.76

Holý P, Hlaváč V, Ostašov P, Brynychová V, Koževnikovová R, Trnková M, Kopečková K, Měšťáková S, Mrhalová M, Souček P. Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype. Biochimie 2022; 199:158-169. doi: 10.1016/j.biochi.2022.04.015. IF₂₀₂₁ = 4.372

Pavek P, Dusek J, Smutny T, Skoda J, Hyrsova L, Soucek P, Vrzal R, Dvorak Z. Gene expression profiling of 1α,25(OH)2D3 treatment in 2D/3D human hepatocyte models reveals CYP3A4 induction but minor changes in other xenobiotic-metabolizing genes. Mol Nutr Food Res 2022; 66(9):e2200070. doi: 10.1002/mnfr.202200070. IF₂₀₂₁ = 6.575

Krus I, Brynychová V, Hlaváč V, Václavíková R, Kováčová M, Koževnikovová R, Kopečková K, Tornikidis J, Vrána D, Gatěk J, Souček P. Single nucleotide variants in KIF14 gene may have prognostic value in breast cancer. Mol Diag Ther 2022;26(6):665-678. doi: 10.1007/s40291-022-00616-z. IF₂₀₂₁ = 4.476

Skarkova V, Vitovcova B, Matouskova P, Manethova M, Kazimirova P, Skarka A, Brynychova V, Soucek P, Vosmikova H, Rudolf E. Role of N-Cadherin in Epithelial-to-Mesenchymal Transition and Chemosensitivity of Colon Carcinoma Cells. Cancers (Basel). 2022;14(20):5146. doi: 10.3390/cancers14205146. IF₂₀₂₁ = 6.575

Peduzzi G, Archibugi L, Katzke V, Gentiluomo M, Capurso G, Milanetto AC, Gazouli M, Goetz M, Brenner H, Vermeulen RCH, Talar-Wojnarowska R, Vanella G, Tavano F, Lucchesi M, Mohelnikova-Duchonova B, Chen X, Kiudelis V, Hegyi P, Oliverius M, Stocker H, Stornello C, Vodickova L, Souček P, Neoptolemos JP, Testoni SGG, Morelli L, Lawlor RT, Basso D, Izbicki JR, Ermini S, Kupcinskas J, Pezzilli R, Boggi U, van Laarhoven HWM, Szentesi A, Erőss B, Capretti G, Schöttker B, Skieceviciene J, Aoki MN, van Eijck CHJ, Cavestro GM, Canzian F, Campa D. Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women. Sci Rep. 2022;12(1):18100. doi: 10.1038/s41598-022-22973-9. IF₂₀₂₁ = 4.575

Rao, BH, Souček P, Hlaváč V. Laser Capture Microdissection: A Gear for Pancreatic Cancer Research. Int. J. Mol. Sci. 2022; 23: 14566. doi: 10.3390/ijms232314566. IF₂₀₂₁ = 6.208

Seborova K, Koucka K, Spalenkova A, Holy P, Ehrlichova M, Sychra T, Chen L, Bendale H, Ojima I, Sandoval-Acuna C, Truksa J, Soucek P, Vaclavikova R. Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model. Front Pharmacol 2022;13:971905. doi: 10.3389/fphar.2022.971905. IF₂₀₂₁ = 5.988

Seborova K, Hlavac V, Holy P, Bjørklund SS, Fleischer T, Rob L, Hruda M, Bouda J, Mrhalova M, Allah MMKAO, Vodicka P, Fiala O, Soucek P, Kristensen VN, Vodickova L, Vaclavikova R. Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy. Front Oncol 2022; 12:1016958. doi: 10.3389/fonc.2022.1016958. IF₂₀₂₁ = 5.738

Giaccherini M, Farinella R, Gentiluomo M, Mohelnikova-Duchonova B, Kauffmann EF, Palmeri M, Uzunoglu F, Soucek P, Petrauskas D, Cavestro GM, Zykus R, Carrara S, Pezzilli R, Puzzono M, Szentesi A, Neoptolemos J, Archibugi L, Palmieri O, Milanetto AC, Capurso G, van Eijck CHJ, Stocker H, Lawlor RT, Vodicka P, Lovecek M, Izbicki JR, Perri F, Kupcinskaite-Noreikiene R, Götz M, Kupcinskas J, Hussein T, Hegyi P, Busch OR, Hackert T, Mambrini A, Brenner H, Lucchesi M, Basso D, Tavano F, Schöttker B, Vanella G, Bunduc S, Petrányi Á, Landi S, Morelli L, Canzian F, Campa D. Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk. Int J Cancer. 2022 Nov 30. doi: 10.1002/ijc.34383. IF₂₀₂₁ = 7.316

Dvorak P, Hanicinec V, Soucek P. The longest intron rule. Front Genetics in press 2023, doi: 10.3389/fgene.2022.1085139. IF₂₀₂₁ = 4.772

2021

Kloudova-Spalenkova A, Holy P, Soucek P. Oxysterols in Cancer Management: From Therapy to Biomarkers. Brit J Pharmacol. 2021;178:3235–3247. doi: 10.1111/bph.15273. IF = 9.479

Bleach R, Madden SF, Hawley J, Charmsaz S, Selli C, Sheehan KM, Young LS, Sims AH, Soucek P, Hill AD, McIlroy M. Steroid ligands, the forgotten triggers of nuclear receptor action; implications for acquired resistance to endocrine therapy. Clin Cancer Res. 2021; 27(14):3980-3989. doi: 10.1158/1078-0432.CCR-20-4135. IF = 13.801

Hlavac V, Vaclavikova R, Brynychova V, Dvorak P, Elsnerova K, Kozevnikovova R, Raus K, Kopeckova K, Mestakova S, Vrana D, Gatek J, Soucek P. SLC46A1 haplotype with predicted functional impact has prognostic value in breast carcinoma. Mol Diag Ther. 2021;25(1):99-110. doi: 10.1007/s40291-020-00506-2.  IF = 4.476

Galeotti AA, Gentiluomo M, Rizzato C, Obazee O, Neoptolemos JP, Pasquali C, Nentwich M, Cavestro GM, Pezzilli R, Greenhalf W, Holleczek B, Schroeder C, Schöttker B, Ivanauskas A, Ginocchi L, Key TJ, Hegyi P, Archibugi L, Darvasi E, Basso D, Sperti C, Bijlsma MF, Palmieri O, Hlavac V, Talar-Wojnarowska R, Mohelnikova-Duchonova B, Hackert T, Vashist Y, Strouhal O, van Laarhoven H, Tavano F, Lovecek M, Dervenis C, Izbéki F, Padoan A, Małecka-Panas E, Maiello E, Vanella G, Capurso G, Izbicki JR, Theodoropoulos GE, Jamroziak K, Katzke V, Kaaks R, Mambrini A, Papanikolaou IS, Szmola R, Szentesi A, Kupcinskas J, Bursi S, Costello E, Boggi U, Milanetto AC, Landi S, Gazouli M, Vodickova L, Soucek P, Gioffreda D, Gemignani F, Brenner H, Strobel O, Büchler M, Vodicka P, Paiella S, Canzian F, Campa D. Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction. J Med Genet. 2021;58(6):369-377. doi: 10.1136/jmedgenet-2020-106961. IF = 5.954

Hlavac V, Vaclavikova R, Brynychova V, Ostasov P, Kozevnikovova R, Kopeckova K, Vrana D, Gatek J, Soucek P. Role of Genetic Variation in Cytochromes P450 in Breast Cancer Prognosis and Therapy Response. Int. J. Mol. Sci. 2021;22:2826. doi: 10.3390/ijms22062826. IF = 6.208

Seborova K, Vaclavikova R, Rob L, Soucek P, Vodicka P. Non-Coding RNAs as Biomarkers of Tumor Progression and Metastatic Spread in Epithelial Ovarian Cancer. Cancers 2021;13: 1839. doi: 10.3390/cancers13081839. IF = 6.575

Bendova P, Pardini B, Susova S, Rosendorf J, Levy M, Skrobanek P, Buchler T, Kral J, Liska V, Vodickova L, Landi S, Soucek P, Naccarati A, Vodicka P, Vymetalkova V. Genetic variations in microRNA binding sites of solute carrier transporter genes as predictors of clinical outcome in colorectal cancer. Carcinogenesis. 2021 42(3):378-394. doi: 10.1093/carcin/bgaa136. IF = 4.741

Corradi C, Gentiluomo M, Gajdán L, Cavestro GM, Kreivenaite E, Di Franco G, Sperti C, Giaccherini M, Petrone MC, Tavano F, Gioffreda D, Morelli L, Soucek P, Andriulli A, Izbicki JR, Napoli N, Małecka-Panas E, Hegyi P, Neoptolemos JP, Landi S, Vashist Y, Pasquali C, Lu Y, Cervena K, Theodoropoulos GE, Moz S, Capurso G, Strobel O, Carrara S, Hackert T, Hlavac V, Archibugi L, Oliverius M, Vanella G, Vodicka P, Arcidiacono PG, Pezzilli R, Milanetto AC, Lawlor RT, Ivanauskas A, Szentesi A, Kupcinskas J, Testoni SGG, Lovecek M, Nentwich M, Gazouli M, Luchini C, Zuppardo RA, Darvasi E, Brenner H, Gheorghe C, Jamroziak K, Canzian F, Campa D. Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. Int J Cancer. 2021;148(11):2779-2788. doi: 10.1002/ijc.33475. IF = 7.316

Hanicinec V, Brynychova V, Rosendorf J, Palek R, Liska V, Oliverius M, Kala Z, Mohelnikova-Duchonova B, Krus I, Soucek P. Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer. Oncol Lett. 2021;22(2):598. doi: 10.3892/ol.2021.12859. IF = 3.111

Gentiluomo M, Corradi C, Vanella G, Johansen AZ, Strobel O, Szentesi A, Milanetto AC, Hegyi P, Kupcinskas J, Tavano F, Neoptolemos JP, Bozzato D, Hackert T, Pezzilli R, Johansen JS, Costello E, Mohelnikova-Duchonova B, van Eijck CHJ, Talar-Wojnarowska R, Hansen CP, Darvasi E, Chen IM, Cavestro GM, Soucek P, Piredda L, Vodicka P, Gazouli M, Arcidiacono PG, Canzian F, Campa D, Capurso G. Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival. Sci Rep. 2021;11(1):7570. doi: 10.1038/s41598-021-87130-0. IF = 4.996

Čaja F, Stakheev D, Chernyavskiy O, Kubinová L, Křížan J, Dvořák J, Rossmann P, Štěpánková R, Makovický P, Makovický P, Vymetalková V, Souček P, Vodička P, Vodičková L, Levý M, Vannucci LE. Local Immune Changes in Early Stages of Inflammation and Carcinogenesis Correlate with the Collagen Scaffold Changes of the Colon Mucosa. Cancers (Basel). 2021;13(10):2463. doi: 10.3390/cancers13102463. IF = 6.575

Pistoni L, Gentiluomo M, Lu Y, López de Maturana E, Hlavac V, Vanella G, Darvasi E, Milanetto AC, Oliverius M, Vashist Y, Di Leo M, Mohelnikova-Duchonova B, Talar-Wojnarowska R, Gheorghe C, Petrone MC, Strobel O, Arcidiacono PG, Vodickova L, Szentesi A, Capurso G, Gajdán L, Malleo G, Theodoropoulos GE, Basso D, Soucek P, Brenner H, Lawlor RT, Morelli L, Ivanauskas A; PanGenEU Study investigators, Kauffmann EF, Macauda A, Gazouli M, Archibugi L, Nentwich M, Loveček M, Cavestro GM, Vodicka P, Landi S, Tavano F, Sperti C, Hackert T, Kupcinskas J, Pezzilli R, Andriulli A, Pollina L, Kreivenaite E, Gioffreda D, Jamroziak K, Hegyi P, Izbicki JR, Testoni SGG, Zuppardo RA, Bozzato D, Neoptolemos JP, Malats N, Canzian F, Campa D. Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma. Carcinogenesis. 2021;42(8):1037-1045. doi: 10.1093/carcin/bgab057. IF = 4.741

Cumova A, Vymetalkova V, Opattova A, Bouskova V, Pardini B, Kopeckova K, Kozevnikovova R, Lickova K, Ambrus M, Vodickova L, Naccarati A, Soucek P, Vodicka P. Genetic variations in 3´UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response. Mutagenesis. 2021; 36(4): 269-279. doi: 10.1093/mutage/geab017. IF = 2.954

Lu Y, Corradi C, Gentiluomo M, López de Maturana E, Theodoropoulos GE, Roth S, Maiello E, Morelli L, Archibugi L, Izbicki JR, Sarlós P, Kiudelis V, Oliverius M, Aoki MN, Vashist Y, van Eijck CHJ, Gazouli M, Talar-Wojnarowska R, Mambrini A, Pezzilli R, Bueno-de-Mesquita B, Hegyi P, Souček P, Neoptolemos JP, Di Franco G, Sperti C, Kauffmann EF, Hlaváč V, Uzunoğlu FG, Ermini S, Małecka-Panas E, Lucchesi M, Vanella G, Dijk F, Mohelníková-Duchoňová B, Bambi F, Petrone MC, Jamroziak K, Guo F, Kolarova K, Capretti G, Milanetto AC, Ginocchi L, Loveček M, Puzzono M, van Laarhoven HWM, Carrara S, Ivanauskas A, Papiris K, Basso D, Arcidiacono PG, Izbéki F, Chammas R, Vodicka P, Hackert T, Pasquali C, Piredda ML, Costello-Goldring E, Cavestro GM, Szentesi A, Tavano F, Włodarczyk B, Brenner H, Kreivenaite E, Gao X, Bunduc S, Vermeulen RCH, Schneider MA, Latiano A, Gioffreda D, Testoni SGG, Kupcinskas J, Lawlor RT, Capurso G, Malats N, Campa D, Canzian F. Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk. Front Genet. 2021;12:693933. doi: 10.3389/fgene.2021.693933. IF = 4.772

Peduzzi G, Gentiluomo M, Tavano F, Arcidiacono PG, Ermini S, Vodicka P, Boggi U, Cavestro GM, Capurso G, Morelli L, Milanetto AC, Pezzilli R, Lawlor RT, Carrara S, Lovecek M, Souček P, Guo F, Hackert T, Uzunoglu FG, Gazouli M, Párniczky A, Kupcinskas J, Bijlsma MF, Bueno-de-Mesquita B, Vermeulen R, van Eijck CHJ, Jamroziak K, Talar-Wojnarowska R, Greenhalf W, Gioffreda D, Petrone MC, Landi S, Archibugi L, Puzzono M, Funel N, Sperti C, Piredda ML, Mohelnikova-Duchonova B, Lu Y, Hlavac V, Gào X, Schneider M, Izbicki JR, Theodoropoulos G, Bunduc S, Kreivenaite E, Busch OR, Małecka-Panas E, Costello E, Perri F, Testoni SGG, Vanella G, Pasquali C, Oliverius M, Brenner H, Loos M, Götz M, Georgiou K, Erőss B, Maiello E, Szentesi A, Bazzocchi F, Basso D, Neoptolemos JP, Hegyi P, Kiudelis V, Canzian F, Campa D. Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk. Cancer Epidemiol Biomarkers Prev. 2021;30(12):2342-2345.2021. doi: 10.1158/1055-9965.EPI-21-0353. IF = 4.090

Lu Y, Gentiluomo M, Macauda A, Gioffreda D, Gazouli M, Petrone MC, Kelemen D, Ginocchi L, Morelli L, Papiris K, Greenhalf W, Izbicki JR, Kiudelis V, Mohelníková-Duchoňová B, Bueno-de-Mesquita B, Vodicka P, Brenner H, Diener MK, Pezzilli R, Ivanauskas A, Salvia R, Szentesi A, Aoki MN, Németh BC, Sperti C, Jamroziak K, Chammas R, Oliverius M, Archibugi L, Ermini S, Novák J, Kupcinskas J, Strouhal O, Souček P, Cavestro GM, Milanetto AC, Vanella G, Neoptolemos JP, Theodoropoulos GE, van Laarhoven HWM, Mambrini A, Moz S, Kala Z, Loveček M, Basso D, Uzunoglu FG, Hackert T, Testoni SGG, Hlaváč V, Andriulli A, Lucchesi M, Tavano F, Carrara S, Hegyi P, Arcidiacono PG, Busch OR, Lawlor RT, Puzzono M, Boggi U, Guo F, Małecka-Panas E, Capurso G, Landi S, Talar-Wojnarowska R, Strobel O, Gao X, Vashist Y, Campa D, Canzian F. Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk. Front Oncol. 2021;11:771312. doi: 10.3389/fonc.2021.771312. IF = 5.738

Seborova K, Kloudova-Spalenkova A, Koucka K, Holy P, Ehrlichova M, Wang Ch, Ojima I, Voleska I, Daniel P, Balusikova K, Jelinek M, Kovar J, Rob L, Hruda M, Mrhalova M, Soucek P, Vaclavikova R. The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes. Int. J. Mol. Sci. 2021; 23:73. doi: 10.3390/ijms23010073. IF = 6.208